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Countermeasures to Circadian Misalignment

Study acronym: C2CM
StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated July 24, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary completion date: Mar 31, 2025 to Jun 30, 2026
    • Study completion date: Jun 30, 2025 to Jun 30, 2026
    v5
  2. Re-verified, no change to tracked fieldsv4
  3. Collaborators: 2 to 3v3
  4. Re-verified, no change to tracked fieldsv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.
Trial Details
NCT Number NCT04966351
Lead Sponsor Colorado State University
Collaborators: University of Colorado, Denver, Salk Institute for Biological Studies, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions
(from sponsor)		 Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
Related terms Insulin Resistance, Metabolic Diseases
Enrollment 32 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov