Clinical Trial

Countermeasures to Circadian Misalignment

Study acronym: C2CM
Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated July 24, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2021-07-07; most recent amendment 2025-07-21.
Trial Details
NCT Number NCT04966351
Lead Sponsor Colorado State University
Collaborators: University of Colorado, Denver, Salk Institute for Biological Studies, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
Enrollment 32 participants
Start Date 2021-07-07
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-07-24