Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group

Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients. The search for outcome predictors is going to be subdivided into three main research areas: 1. outcome predictors in the emergency department (so called "early brain injury phase"). 2. outcome predictors in the neurocritical care unit (so called "delayed brain injury phase"). 3. Treatment strategies. Two other areas of research are identified: delayed cerebral ischemia (incidence, treatment, predictors, impact on outcome) and long term follow-up (recent evidences suggest that there may be a non-negligible proportion of poor grade subarachnoid hemorrhage patients who may benefit from substantial improvement at long-term (after 6-12 months of follow-up).

NCT Number	NCT04945603
Lead Sponsor	IRCCS San Raffaele Collaborators: Azienda Ospedaliera Universitaria Integrata Verona, Azienda Ospedaliero-Universitaria di Parma, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, A.O. Ospedale Papa Giovanni XXIII, ASL Taranto, Ospedale V. Fazzi, IRCCS Istituto delle Scienze Neurologiche di Bologna, Azienda Ospedaliero Universitaria Maggiore della Carita
Conditions	Subarachnoid Hemorrhage, Aneurysmal, Poor Grade Subarachnoid Hemorrhage
Enrollment	800 participants
Start Date	2021-05-25
Primary Completion	2025-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2023-11-29