Clinical Trial

Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring

Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied. This is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2021-06-16; most recent amendment 2026-04-21.
Status change: Not Yet Recruiting → Recruiting 2022-07-07
Trial Details
NCT Number NCT04938765
Lead Sponsor Loma Linda University
Conditions Intraoperative Neurophysiological Monitoring, Magnesium Sulfate
Enrollment 50 participants
Start Date 2022-03-18
Primary Completion 2027-03 (estimated)
Study Completion 2027-03 (estimated)
Updated on ClinicalTrials.gov 2026-04-24