Clinical Trial

The GUARDIAN Trial - Vasopressor Sub-Study

Enrolling by Invitation Phase 4
View on ClinicalTrials.gov →
Summary
This is a sub-study of the overall GUARDIAN trial (NCT04884802) in which some GUARDIAN trial participants will be additionally randomized to norepinephrine or phenylephrine infusion to maintain the designated target intraoperative mean arterial pressure.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2021-06-15; most recent amendment 2025-08-23.
Status change: Not Yet Recruiting → Enrolling by Invitation 2021-08-17
Trial Details
NCT Number NCT04934748
Lead Sponsor The University of Texas Health Science Center, Houston
Conditions Blood Pressure
Enrollment 6,254 participants
Start Date 2021-07-25
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-04-25 (estimated)
Updated on ClinicalTrials.gov 2025-08-29