Clinical Trial

The GUARDIAN Trial - Induction Agent Sub-Study

Enrolling by Invitation Phase 4
View on ClinicalTrials.gov →
Summary
This is a sub-study of the overall GUARDIAN trial (NCT04884802) in which some GUARDIAN trial participants will be additionally randomized to etomidate vs propofol for anesthetic induction.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2021-06-15; most recent amendment 2025-08-23.
Status change: Recruiting → Enrolling by Invitation 2025-08-23
Status change: Not Yet Recruiting → Recruiting 2021-07-27
Trial Details
NCT Number NCT04934683
Lead Sponsor The University of Texas Health Science Center, Houston
Conditions Major Surgery
Enrollment 6,254 participants
Start Date 2021-07-25
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-04-25 (estimated)
Updated on ClinicalTrials.gov 2025-08-29