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Efficacy of Preventive Ketamine on Postoperative Pain

StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated July 7, 2026 (before its estimated September 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary and study completion pushed from May 31, 2026 to Sep 30, 2026v15
  2. Primary and study completion dates: Feb 28, 2026 to May 31, 2026v14
  3. Primary and study completion dates: Aug 31, 2025 to Feb 28, 2026v13
  4. Primary and study completion dates: Mar 31, 2025 to Aug 31, 2025v12
  5. Primary and study completion dates: Sep 30, 2024 to Mar 31, 2025v11
Show 9 earlier versionsHide 9 earlier versions
  1. Primary and study completion dates: Apr 30, 2024 to Sep 30, 2024v10
  2. Primary and study completion dates: Dec 31, 2023 to Apr 30, 2024v9
  3. Primary and study completion dates: Sep 30, 2023 to Dec 31, 2023v8
  4. Primary and study completion dates: Mar 15, 2023 to Sep 30, 2023v7
  5. Primary and study completion dates: Dec 15, 2022 to Mar 15, 2023v6
  6. Primary and study completion dates: Sep 30, 2022 to Dec 15, 2022v5
  7. Primary and study completion dates: Apr 30, 2022 to Sep 30, 2022v4
  8. Primary and study completion dates: Dec 15, 2021 to Apr 30, 2022v3
  9. Trial status: Not Yet Recruiting to Recruiting Site details revisedv2 Show 1 more changeShow less
    • Site details revised
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
* Although bariatric surgery is mainly performed laparoscopically, analgesic optimization is still essential to reduce complications and to improve the patients' comfort. In laparoscopic sleeve gastrectomy, the intraoperative peritoneal instillation of bupivacaine hydrochloride (30 ml, 0.25%) was known to be safe and effective in reducing postoperative pain, nausea, and vomiting. * Furthermore, usage of ketamine both as a pre and post-operative pain management is well established. Ketamine can be used solely or in combination with other co-adjuvant drugs, increasing their efficacy. Many therapeutic properties of ketamine have been attributed to its antagonism mechanism to N-Methyl-D-aspartate receptors.
Trial Details
NCT Number NCT04908579
Lead Sponsor Ain Shams University
Conditions Postoperative Pain
Enrollment 90 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov