Mobile Contingency Management for Smoking Cessation

The purpose of the proposed project is to evaluate an automated mobile phone-based CM approach that will allow socioeconomically disadvantaged individuals to remotely benefit from financial incentives for smoking cessation. The investigators have previously combined technologies including 1) portable carbon monoxide monitors that connect with mobile phones to remotely verify smoking abstinence, 2) facial recognition software to confirm participant identity during breath sample submissions, and 3) remote delivery of incentives automatically triggered by biochemical confirmation of self-reported abstinence. This automated CM approach will be evaluated in a randomized controlled trial that includes 532 socioeconomically disadvantaged males and females seeking smoking cessation treatment. Participants will be randomly assigned to either telephone counseling and nicotine replacement therapy (standard care \[SC\]) or SC plus a mobile financial incentives intervention (CM) for biochemically-confirmed abstinence. Participants will be followed for 26 weeks after a scheduled quit attempt. Biochemically-verified 7-day point prevalence abstinence at 26 weeks post-quit will be the primary outcome variable. Cost-effectiveness will be evaluated to inform policy-related decisions. Potential mobile CM treatment mechanisms, including self-efficacy, motivation, and treatment engagement, will be explored to optimize future versions of the intervention.

NCT Number	NCT04881630
Lead Sponsor	University of Oklahoma Collaborators: National Cancer Institute (NCI), University of California, Los Angeles, University of Florida, H. Lee Moffitt Cancer Center and Research Institute
Conditions	Smoking Cessation
Enrollment	532 participants
Start Date	2022-11-08
Primary Completion	2025-09-21 (estimated)
Study Completion	2025-09-21 (estimated)
Updated on ClinicalTrials.gov	2026-07-24