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Twin Block, Pain Medications and Third Molar Extractions

StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated June 22, 2026 (before its estimated August 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Minor Primary completion date: Feb 2026 to Aug 2026
    • Study completion date: Aug 2026 to Dec 2026
    v9
  2. Minor Primary completion date: Nov 2025 to Feb 2026
    • Study completion date: Mar 2026 to Aug 2026
    v8
  3. Notable Trial status: Not Yet Recruiting to Recruitingv7 Show 4 more changesShow less
    • Primary completion date: Nov 2024 to Nov 2025
    • Study completion date: Dec 2024 to Mar 2026
    • Start date changed from estimate of Mar 2024 to Mar 11, 2024
    • Site details revised
  4. Notable Primary completion date: Apr 2024 to Nov 2024
    • Start date: Dec 2023 to Mar 2024
    v6
  5. Notable Start date: May 2023 to Dec 2023v5
Show 3 earlier versionsHide 3 earlier versions
  1. Notable Primary completion date: Oct 2022 to Apr 2024
    • Start date: May 2022 to May 2023
    • Study completion date: Dec 2022 to Dec 2024
    v4
  2. Notable Primary completion date: Feb 2022 to Oct 2022
    • Start date: Jun 2021 to May 2022
    • Study completion date: Jun 2022 to Dec 2022
    v3
  3. Minor Re-verified, no change to tracked fieldsv2
  1. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Each year, over 3.5 million, mostly, healthy young adults, have their third molar teeth ('wisdom teeth') removed under sedation and are often given opioid prescriptions for managing their pain. Wisdom molar removal is one of the most common reasons for opioid prescriptions to be given to adolescents. There is a national thrust to reduce both the dose and the duration of such opioid prescriptions because even short-term opioid exposures increase risk for narcotic addiction and misuse. Non-opioid options to manage pain will still allow for sufficient pain control without risking addiction, and hence, a fundamental component of our response to combat the current national opioid crisis. The investigators are going to study a promising option- the Twin Block dental anesthetic injection. The Twin block involves injecting the standard dental numbing medication in a way that 'numbs' the 'jaw-clencher' muscles on the side of the face. The investigators found that the Twin block relieved jaw pain stemming from these muscles, in a quick and sustained manner, even in patients whose pain following wisdom tooth removal primarily came from 'taut' and tender jaw-clencher muscles. However, what is not known is- how often do patients who have their wisdom teeth removed under sedation, end up in significant pain from taut and tender jaw-clencher muscles? Will using the twin block effectively reduce pain in such patients? In this pilot study, the investigators will examine wisdom molar extraction patients one day after their procedure. Those with significant pain (pain rated ≥ 5 on a 0-10 scale) in their jaw-clencher muscles, will get either the Twin block injection or a placebo. The investigators will track both 1) pain before and after the injection, and 2) pain medication usage over a 7-day period to see if both pain and opioid dosage come down with the Twin block. This study can support a simple, safe and inexpensive means to reduce pain after a common procedure.
Trial Details
NCT Number NCT04880707
Lead Sponsor Rutgers, The State University of New Jersey
Collaborators: New Jersey Health Foundation
Conditions
(from sponsor)
Acute Pain
Related terms Acute Pain
Enrollment 48 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov