Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT04878549 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Transcriptomic Responses for the Identification of Pathogens

Study acronym: TRiP
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated March 3, 2025 (before its estimated June 2025 completion). Its status may not reflect the trial's current state.

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion date: Jan 2024 to Jun 2025
    • Study completion date: Jun 2024 to Jun 2025
    • Eligibility criteria expanded, about 8 words
    • Collaborators: 1 to 2
    v4
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Jan 2022 to May 2, 2022
    • Eligibility criteria revised
    v3
  3. Primary completion date: Jun 2023 to Jan 2024
    • Start date: Jun 2021 to Jan 2022
    • Study completion date: Dec 2023 to Jun 2024
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions. Assessment of the host gene expression response to infection in endemic populations has demonstrated significant promise as a new approach to identifying patients with enteric fever and for potential in differentiating between other causes of AUFI. Signatures identified through new data analytic techniques could be developed into a point-of-care test for use in endemic settings. In this multisite diagnostic evaluation study we will collect prospective clinical, laboratory and diagnostic data from two endemic settings to evaluate host gene expression signatures for detecting enteric fever and for determining the cause of AUFI in LMIC settings.
Trial Details
NCT Number NCT04878549
Lead Sponsor University of Sheffield
Collaborators: Christian Medical College, Vellore, India, KEMRI-Wellcome Trust Collaborative Research Program
Conditions
(from sponsor)		 Enteric Fever, Acute Febrile Illness, Typhoid, Paratyphoid Fever, Fever
Related terms Fever, Paratyphoid Fever, Typhoid Fever
Enrollment 2,000 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov