Clinical Trial

Tissue Engineering Approaches to Treat COPD

Active, Not Recruiting
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Summary
The study is a pilot/laboratory study comparing lung tissue from control participants with tissue from COPD participants with a chronic bronchitis or emphysema phenotypes. Tissue will be characterised mechanically and biochemically. Lung cells, including DASCp63/Krt5 with a possible role in disease pathology, will be isolated, expanded in vitro, characterised, and banked. Biomaterials will be selected and tested with regards to mechanical and physical properties and selected for use in the production of TELEs with properties matched to healthy and diseased lung tissue. The resulting TELEs will be tested in an ex vivo tissue culture model to determine the extent of their integration with lung.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2021-05-05; most recent amendment 2025-02-03.
Status change: Recruiting → Active, Not Recruiting 2025-02-03
Trial Details
NCT Number NCT04878445
Lead Sponsor University Hospitals of North Midlands NHS Trust
Conditions Lung Cancer
Enrollment 30 participants
Start Date 2017-08-31
Primary Completion 2024-12-31 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-02-04