Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide Release

The worldwide increase in the prevalence of obesity is a cause of great concern. Pharmacological treatment options are being explored at the moment with a major focus on the hormones produced by the gastrointestinal tract which regulate hunger and satiation/satiety. Modulating the release of these hormones via bitter substances reduced appetite-related sensations and gastrointestinal motility in lean female volunteers. Intragastric administration of a quinine-solution has shown to decrease hunger sensations in healthy female volunteers. Now, we want to examine whether this effect is still seen in an overweight female population.

NCT Number	NCT04873011
Lead Sponsor	Universitaire Ziekenhuizen KU Leuven
Conditions	Obesity
Enrollment	40 participants
Start Date	2020-10-29
Primary Completion	2025-10-29 (estimated)
Study Completion	2025-10-29 (estimated)
Updated on ClinicalTrials.gov	2024-07-03