Improving Low ASPECTS Stroke Thrombectomy

Improving Low ASPECTS Stroke Thromectomy (I-LAST) is an academic, independent, prospective, multicenter, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Patients receive regular care and data will be collected as part of clinical routine. Baseline clinical and procedural information as well clinical follow-up information during in-hospital stay, and up to 90 days of stroke onset are collected. Data collected include demographics, National Institute of Health Stroke Scale (NIHSS) on admission, pre-treatment ASPECTS, information on timing and success of interventional treatment, procedural complications, intracranial hemorrhage, and functional outcome. Advanced imaging biomarkers will be tested and validated aiming to improve treatment selection and outcome prediction of patients presenting with extensive baseline infarction.

NCT Number	NCT04862507
Lead Sponsor	Universitätsklinikum Hamburg-Eppendorf Collaborators: University of Kaiserslautern, University Hospital Muenster, University of Rostock, University Hospital, Basel, Switzerland, Charite University, Berlin, Germany, Klinikum Bremen-Mitte, gGmbH
Conditions	Acute Ischemic Stroke
Enrollment	500 participants
Start Date	2023-05-01
Primary Completion	2027-01-01 (estimated)
Study Completion	2028-01-01 (estimated)
Updated on ClinicalTrials.gov	2023-05-24