Genome Sequencing in the Intensive Care Unit Population

The purpose of this study is to understand how the use of whole genome sequencing (WGS) may be able to increase the speed with which a diagnosis is made for patients in an intensive care unit population. This is not an assessment of a new device, test, or technology. This project is an investigation of the utility of this technology in clinical care when compared to standard of care testing. The study will look at the ability to more quickly diagnose a patient (time to diagnosis and efficacy of testing) as compared to standard of care testing. The study will also look at the impact of WGS on patient outcomes and cost of clinical care.

NCT Number	NCT04848090
Lead Sponsor	Jerry Vockley, MD, PhD
Conditions	Infant, Newborn, Disease, Genetic Disease
Enrollment	400 participants
Start Date	2020-07-13
Primary Completion	2027-02 (estimated)
Study Completion	2027-06 (estimated)
Updated on ClinicalTrials.gov	2026-01-09