Optimal Non-invasive Brain Stimulation for Peripheral Vision

Glaucoma is a complex disease that can result in progressive vision loss. There are no treatments that restore vision lost to glaucoma. However, recent studies have shown that vision can be improved by non-invasive brain (NIBS) stimulation and visual training. In this study, we aim to compare and find out the optimal non-invasive brain stimulation model (transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and transcranial random noise stimulation (tRNS)) for improving peripheral vision in glaucoma patients. The proposed treatment is the application of transcranial electrical stimulation (tES) onto the participant's head, with brain stimulation aimed at the Primary Visual Cortex toward the occipital pole. The investigators hypothesize that the tES will enable higher performance in the reading task and secondary measures due to an increase in the cortical excitability of the stimulated brain cells, and tRNS will generate the greatest acute improvement in peripheral vision than either a-tDCS, tACS, or sham stimulation.

NCT Number	NCT04846140
Lead Sponsor	The Hong Kong Polytechnic University Collaborators: Chinese University of Hong Kong, The University of Hong Kong, University of Waterloo, Hong Kong Metropolitan University, Otto-von-Guericke University Magdeburg
Conditions	Glaucoma
Enrollment	40 participants
Start Date	2021-11-01
Primary Completion	2025-07 (estimated)
Study Completion	2025-09 (estimated)
Updated on ClinicalTrials.gov	2024-10-29