Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT04806282 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

The 50 most recent of 215 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fieldsv215
  2. Trial status: Suspended to Recruiting Enrollment target: 58 to 210 · Site details revisedv214 Show 2 more changesShow less
    • Enrollment target: 58 to 210
    • Site details revised
  3. 3 versions Re-verified since Dec 5, 2025, no change to tracked fieldsv211-v213
  4. Enrollment target: 17 to 58v210
  5. Re-verified, no change to tracked fieldsv209
Show 43 earlier versionsHide 43 earlier versions
  1. Trial status: Recruiting to Suspended Sponsor's reason: Pause in study enrollment due to PI departure from NIH. IC leadership and the new PI have initiated a pause in the enrollment of new… Enrollment target: estimated 210 to confirmed 17 · Site details revisedv208 Show 2 more changesShow less
    • Enrollment target: estimated 210 to confirmed 17
    • Site details revised
  2. Re-verified, no change to tracked fieldsv207
  3. Study description shortened, about 21 wordsv206 See this version in full on ClinicalTrials.gov ↗
  4. 6 versions Re-verified since Sep 24, 2024, no change to tracked fieldsv200-v205
  5. Eligibility criteria shortened, about 40 wordsv199 See this version in full on ClinicalTrials.gov ↗
  6. 8 versions Re-verified since Mar 3, 2023, no change to tracked fieldsv191-v198
  7. Eligibility criteria revisedv190 See this version in full on ClinicalTrials.gov ↗
  8. 4 versions Re-verified since Sep 17, 2022, no change to tracked fieldsv186-v189
  9. Eligibility criteria expanded, about 3 wordsv185 See this version in full on ClinicalTrials.gov ↗
  10. Enrollment target: 150 to 210 Eligibility criteria expanded, about 115 words · Study description shortened, about 17 wordsv184 Show 2 more changesShow less
    • Eligibility criteria expanded, about 115 words
    • Study description shortened, about 17 words

    See this version in full on ClinicalTrials.gov ↗

  11. 18 versions Re-verified since Jun 7, 2022, no change to tracked fieldsv166-v183
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background: Disorders of hearing instability (HI) are poorly characterized and ineffectively treated. HI can cause fluctuations in hearing thresholds and speech understanding. Researchers want to use a specialized form of magnetic resonance imaging (MRI) and blood tests to learn more about HI. Objective: To characterize a cohort of people with HI and to correlate HI with other data, including hearing evaluations, as well as radiologic and immunologic biomarkers of inflammation over time. Eligibility: Adults ages 18-80 who have symptoms consistent with possible HI. Design: Participants will be screened with a medical and hearing history and medical record review. Participants will have physical exams. Their head and neck will be examined. They will have blood drawn. Participants will have hearing tests. They will wear headphones or foam earplugs. They will listen to different tones. They may describe what they hear. Participants will have balance tests. They will wear goggles as they watch moving lights or while cold or warm air is blown into their ears. They will sit in a spinning chair in a quiet, dark booth. From a reclining position, they will raise their head while clicking sounds are played into their ears. Participants will have MRIs of the inner ear and brain. The MRI scanner is a metal cylinder surrounded by a strong magnetic field. During the MRIs, participants will lie on a table that slides in and out of the scanner. Soft padding or a coil will be placed around their head. They will get a contrast agent through an intravenous catheter. Participation will last up to 15 months. ...
Trial Details
NCT Number NCT04806282
Lead Sponsor National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions Meniere's Disease, Enlarged Vestibular Aqueduct Syndrome, Autoimmune Inner Ear Disease
Enrollment 210 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov