Clinical Trial

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

Study acronym: SNOW
Active, Not Recruiting Phase 2/3
View on ClinicalTrials.gov →
Record status
This record was last updated October 28, 2025 (before its estimated May 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline. This combined intervention should be acceptable, tolerable and safe in this population. To test this, investigators are conducting a trial comparing the efficacy of a number of washes in reducing the oral and nasal SARS-CoV-2 viral load among adults.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2021-03-16; most recent amendment 2025-10-24.
Status change: Recruiting → Active, Not Recruiting 2025-10-24
Status change: Not Yet Recruiting → Recruiting 2021-11-03
Trial Details
NCT Number NCT04802408
Lead Sponsor Milton S. Hershey Medical Center
Collaborators: AXIOM Real Time Metrics, Analytica Ventures LLC
Conditions Covid19, SARS-CoV Infection
Enrollment 171 participants
Start Date 2021-10-01
Primary Completion 2026-05-30 (estimated)
Study Completion 2026-05-30 (estimated)
Updated on ClinicalTrials.gov 2025-10-28