Clinical Trial

Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain

Active, Not Recruiting Early Phase 1
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Summary
Chronic Pain Management (CPM) has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (a greater exposure in vulnerable individuals), non-pain health consequences (hormone changes, falls), and a dramatic rise in opioid-related overdoses and deaths. Treatment strategies that minimize the need for chronic high-dose opioids are sorely needed. This project will aim to test what degree mindfulness therapy (MT) and spinal manipulation therapy (SMT) produce pre- to mid- to post-treatment changes in endogenous opioid (EO) function.
Protocol Amendment History 10 amendments
This ClinicalTrials.gov record has been amended 10 times since 2021-02-04; most recent amendment 2025-07-08.
Status change: Recruiting → Active, Not Recruiting 2024-10-07
Trial Details
NCT Number NCT04744883
Lead Sponsor Rush University Medical Center
Collaborators: Vanderbilt University Medical Center
Conditions Chronic Low-back Pain
Enrollment 140 participants
Start Date 2020-08-15
Primary Completion 2024-11-29 (estimated)
Study Completion 2026-06-01 (estimated)
Updated on ClinicalTrials.gov 2025-07-10