Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its Progression

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss worldwide, and nearly two million Australians have some signs of AMD. This proposed project is a prospective, observational study that seeks to to understand the underlying aetiology of AMD, factors associated with differences between age-related macular degeneration (AMD) phenotypes or severities, or between AMD and healthy individuals. It also seeks to understand the natural history of AMD progression and the factors associated with the rate of progression. In this project, the disease phenotype, genotype and severity and rate of progression will be determined based on non-invasive clinical imaging or functional assessment of the retina, from obtaining biological samples from the participants, or from patient-reported outcomes.

NCT Number	NCT04739319
Lead Sponsor	Center for Eye Research Australia
Conditions	Age Related Macular Degeneration, Geographic Atrophy, AMD, Age-related Macular Degeneration
Enrollment	2,500 participants
Start Date	2021-02-02
Primary Completion	2040-11 (estimated)
Study Completion	2040-11 (estimated)
Updated on ClinicalTrials.gov	2024-02-09