Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

Osteoarthritis (OA), the most common type of arthritis, affects more than 32.5 million adults in the United States. It is also among the most expensive condition to treat when joint replacement surgery is required. Although biomechanics plays an important role in OA disease, the non-surgical treatment options addressing biomechanics are scarce with limited effect. AposHealth is the fist biomechanical treatment that was shown to have a significant short-term effect on patients with knee OA. The main objectives of this study are: 1. To assess AposHealth, a non-invasive home-based biomechanical treatment, as an alternative treatment for patients who are eligible for Total Knee Replacement (TKR). 2. To assess AposHealth as a new post-operative rehabilitation tool for patients post TKR.

NCT Number	NCT04732962
Lead Sponsor	Geisinger Clinic Collaborators: Apos Medical and Sports Technology Ltd.
Conditions	Osteoarthritis, Knee
Enrollment	150 participants
Start Date	2021-07-22
Primary Completion	2026-03 (estimated)
Study Completion	2026-03 (estimated)
Updated on ClinicalTrials.gov	2025-04-30