3DUS Imaging of Needles in Gynecological Brachytherapy

Brachytherapy treatment in gynecological cancers is an essential component to delivering adequate doses of radiation to a tumour while sparing normal tissue. Interstitial or intra-cavitary brachytherapy are often needed in advanced or recurrent disease, in cases where intrauterine brachytherapy may not deliver the optimal outcome. Interstitial or intra-cavitary brachytherapy are based on a defined template-and-needle system, and the procedure relies on clinical examination and pre-treatment imaging to guide needle insertion. There is currently no standard image-guided process to help direct needles in the pelvis. We propose using 3D ultrasound to provide real-time imaging for the brachytherapy procedure, which will aid in avoiding needle insertion into pelvic organs and result in optimal dose coverage to the tumour.

NCT Number	NCT04705467
Lead Sponsor	Western University, Canada
Conditions	Gynecologic Cancer
Enrollment	35 participants
Start Date	2022-10-15
Primary Completion	2025-10 (estimated)
Study Completion	2026-06 (estimated)
Updated on ClinicalTrials.gov	2025-04-13