Clinical Trial

Advanced Techniques for Single-fraction Palliative Radiotherapy Versus ASPIRE-single

Study acronym: ASPIRE single
Active, Not Recruiting
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Summary
One third of patients treated in the radiation oncology departments are treated with palliative intent. These patients can be unwell due to their advanced disease and suffering from pain and other symptoms related to metastases. Radiation therapy (RT) has an important role in the symptomatic relief and improvement in the quality of life (QoL) for these patients.The aim of the study is to determine if escalated single fraction palliative radiotherapy using intensity-modulated techniques results in a prolonged duration of benefit for patients otherwise suitable for standard single fraction radiotherapy.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2020-12-01; most recent amendment 2026-02-03.
Status change: Recruiting → Active, Not Recruiting 2026-02-03
Status change: Not Yet Recruiting → Recruiting 2021-06-10
Trial Details
NCT Number NCT04658537
Lead Sponsor Royal North Shore Hospital
Conditions Palliative Radiotherapy, Radiotherapy, Intensity-Modulated
Enrollment 100 participants
Start Date 2021-06-29
Primary Completion 2024-10-04 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-05