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Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU

Study acronym: TrainToWean
StatusRecruiting
PhaseNot applicable
SponsorKU Leuven
Started
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Record History

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  1. 2 versions Re-verified since Jun 5, 2024, no change to tracked fieldsv5-v6
  2. Trial status: Not Yet Recruiting to Recruiting
    • Primary and study completion dates: Oct 2025 to Oct 2026
    • Start date changed from estimate of Oct 2022 to Feb 1, 2023
    • Site details revised
    v4
  3. Start date: Oct 2021 to Oct 2022v3
  4. Interventions: Procedure: Endurance inspiratory muscle training (Other), Procedure: Strength inspiratory muscle training (Other), Procedure: Usual Care… to Procedure: UC + HI-IMT (Other), Procedure: UC + LI-IMT (sham IMT) (Other), Procedure: Usual Care (UC) (Other)
    • Study description shortened, about 52 words
    v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
KU Leuven
69 trials monitored
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Mechanical ventilation is a life-saving treatment frequently applied in intensive care unit (ICU). Nonetheless, by putting at rest the respiratory muscles, it can lead to respiratory muscle weakness and atrophy, which are accompanied by prolonged duration of mechanical ventilation, difficult weaning and increased ICU mortality. Despite a strong theoretical rationale and some evidence supporting the use of inspiratory muscle training (IMT) to address respiratory muscle weakness and atrophy, the optimal approach to IMT remains largely uncertain. In fact, mechanistic studies evaluating physiological adaptations that occur in respiratory muscles of mechanically ventilated patients in response to different training regimens have not been conducted so far. The aim of this study is to comprehensively investigate changes in respiratory muscle function in response to three different conditions that patients will be exposed to during their period of weaning from mechanical ventilation.
Trial Details
NCT Number NCT04658498
Lead Sponsor KU Leuven
Conditions
(from sponsor)		 Weaning Failure
Enrollment 90 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov