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The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study

Study acronym: WASABI
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated January 14, 2026 (before its estimated February 26, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Minor Primary completion date: Dec 26, 2025 to Feb 26, 2026 Completion date: Dec 26, 2025 to Dec 26, 2026v10 Show 1 more changeShow less
    • Completion date: Dec 26, 2025 to Dec 26, 2026
  2. Minor Re-verified, no change to tracked fieldsv9
  3. Notable Primary and study completion dates: Dec 26, 2024 to Dec 26, 2025v8
  4. Notable Primary and study completion dates: Dec 26, 2023 to Dec 26, 2024v7
  5. Minor Re-verified, no change to tracked fieldsv6
Show 4 earlier versionsHide 4 earlier versions
  1. Notable Primary and study completion dates: Dec 26, 2022 to Dec 26, 2023v5
  2. Notable Primary and study completion dates: Jun 1, 2022 to Dec 26, 2022v4
  3. Notable Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Mar 1, 2021 to Mar 19, 2021 · Site details revisedv3 Show 2 more changesShow less
    • Start date changed from estimate of Mar 1, 2021 to Mar 19, 2021
    • Site details revised
  4. Minor Primary and study completion dates: Mar 1, 2022 to Jun 1, 2022v2
  1. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This functional magnetic-resonance imaging study of the brain will feature a within-subject crossover design to investigate the effects of a placebo cream on painful thermal stimulation rendered upon eight body sites. The investigators aim to 1.) improve the understanding of how the brain represents thermal pain responses somatotopically (i.e., across different body-sites) 2.) to test these brain representations with and without the presence of a pain-targeted placebo intervention, and 3.) to examine how these brain representations change prior to vs. during the delivery of thermal pain. They predict that placebo cream will downregulate the intensity of aversive brain activity representations, and to a lesser degree, sensation and somatotopic representations, both prior to and during painful thermal stimulation.
Trial Details
NCT Number NCT04653064
Lead Sponsor Trustees of Dartmouth College
Conditions Pain
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov