Clinical Trial

The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

Not Yet Recruiting Early Phase 1
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Summary
The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2020-11-24; most recent amendment 2025-12-02.
Trial Details
NCT Number NCT04650841
Lead Sponsor Trustees of Dartmouth College
Conditions Pain, Rejection, Placebo Effect
Enrollment 60 participants
Start Date 2026-09-01
Primary Completion 2027-03-01 (estimated)
Study Completion 2027-03-01 (estimated)
Updated on ClinicalTrials.gov 2025-12-09