Clinical Trial

Advanced Techniques For Single-fraction Palliative Radiotherapy Versus Standard Multi Fraction Radiation

Study acronym: ASPIRE_Multi
Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated February 6, 2026 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
The aim of the study is to determine if single fraction dose escalated palliative radiotherapy results in a prolonged duration of benefit for patients otherwise suitable for Multifraction (5-10#) palliative radiation. The primary endpointis to determine the percentage of patients who have achieved a substantial benefit from palliative radiotherapy and have not redeveloped symptoms by 12 months post treatment
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2020-11-24; most recent amendment 2026-02-04.
Status change: Not Yet Recruiting → Recruiting 2021-06-10
Trial Details
NCT Number NCT04649125
Lead Sponsor Royal North Shore Hospital
Collaborators: Northern Sydney and Central Coast Area Health Service
Conditions Palliative Radiotherapy
Enrollment 100 participants
Start Date 2021-05-31
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-02-06