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Context Interventions: Social Modeling and Initial Treatment Experience

StatusNot Yet Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Dec 1, 2026 to Dec 1, 2027 Start date: Dec 1, 2025 to Dec 1, 2026 · Completion date: Dec 1, 2026 to Dec 1, 2028v8 Show 2 more changesShow less
    • Start date: Dec 1, 2025 to Dec 1, 2026
    • Completion date: Dec 1, 2026 to Dec 1, 2028
  2. Primary and study completion dates: Dec 1, 2025 to Dec 1, 2026 Start date: Dec 1, 2024 to Dec 1, 2025v7 Show 1 more changeShow less
    • Start date: Dec 1, 2024 to Dec 1, 2025
  3. Primary and study completion dates: Dec 1, 2024 to Dec 1, 2025 Start date: Oct 1, 2024 to Dec 1, 2024v6 Show 1 more changeShow less
    • Start date: Oct 1, 2024 to Dec 1, 2024
  4. Start date: Oct 1, 2023 to Oct 1, 2024v5
  5. Primary and study completion dates: Jun 1, 2023 to Dec 1, 2024 Start date: Oct 1, 2022 to Oct 1, 2023v4 Show 1 more changeShow less
    • Start date: Oct 1, 2022 to Oct 1, 2023
Show 2 earlier versionsHide 2 earlier versions
  1. Start date: Oct 1, 2021 to Oct 1, 2022v3
  2. Secondary endpoints: details revised at 1 of 5 entriesv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
In this experiment, the investigators study the brain pathways underlying several promising context interventions that enhance the strength of placebo effects. Specifically, the investigators examine the separate and joint effects of two of the most powerful context interventions: Social modeling-observing someone else being effectively treated-and prior treatment success or failure experiences. Participants will be randomized into 4 groups (Social modeling: observed success vs. observed failure and Conditioning: experienced success vs. experienced failure). The objectives are to investigate the placebo effect on pain relief and aversive image stimuli between and within-subjects. Each group will undergo a behavioral induction phase, fMRI placebo test phase, and an identical 3-month follow up fMRI placebo test phase. Follow-up assessment will provide some of the first evidence on predictors of the durability of placebo and context interventions.
Trial Details
NCT Number NCT04646460
Lead Sponsor Trustees of Dartmouth College
Conditions Placebo Effect, Pain
Enrollment 120 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov