Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound

This is an open-label, non-randomized study conducted at Thomas Jefferson University comparing pressure-gradient estimates (obtained between a carotid plaque and the carotid artery) to imaging and histology markers of plaque vulnerability. There is an inverse relationship between the subharmonic signal magnitude from contrast-enhanced ultrasound microbubbles and ambient pressure. This pressure estimation technique (referred as SHAPE) will be used to estimate the pressure gradient across the carotid plaque cap noninvasively in vivo.

NCT Number	NCT04643431
Lead Sponsor	Thomas Jefferson University
Conditions	Carotid Atherosclerosis
Enrollment	20 participants
Start Date	2020-12-01
Primary Completion	2023-04-05 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-24