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OSA as a Remote Ischemic Preconditioning in Vascular Surgery

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Dec 31, 2025 to Dec 31, 2028
    • Study completion date: Jan 31, 2026 to Jan 31, 2029
    v6
  2. Re-verified, no change to tracked fieldsv5
  3. Primary completion date: Dec 31, 2024 to Dec 31, 2025
    • Study completion date: Jan 31, 2025 to Jan 31, 2026
    v4
  4. Primary completion date: Dec 31, 2022 to Dec 31, 2024
    • Study completion date: Jan 31, 2023 to Jan 31, 2025
    v3
  5. Re-verified, no change to tracked fieldsv2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure. Remote ischemic preconditioning (short periods of ischemia in anticipation of longer period of ischemia) may act protectively against ischemia. Studies of ischemic preconditioning in patients with AAA are conflicting. Obstructive sleep apnea (OSA) is a sleep disordered breathing syndrome which may have a protective effect against ischemia. The investigators hypothesize that I/R injury will be less pronounced in patients who have OSA and that the extent of I/R injury will inversely correlate with OSA severity. Accordingly, the aim of this study is to compare postoperative complications and markers of I/R in patients undergoing elective AAA repair who do and do not have OSA.
Trial Details
NCT Number NCT04630535
Lead Sponsor St. Anne's University Hospital Brno, Czech Republic
Collaborators: Masaryk University
Conditions
(from sponsor)		 Obstructive Sleep Apnea, Vascular Aneurysm, Ischemia Reperfusion Injury
Related terms Reperfusion Injury, Sleep Apnea, Obstructive
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov