Clinical Trial

Explosive Synchronization of Brain Network Activity in Chronic Pain

Active, Not Recruiting
View on ClinicalTrials.gov →
Summary
This project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM). The study design has three components, however, only 2 aims are enrolling participants. The first part (Aim1) is a cross sectional assessment of brain network explosive synchronization activity, connectivity, and response to pain in healthy controls and age and sex-matched fibromyalgia patients; the third part (Aim 3) is a longitudinal assessment of fibromyalgia patients undergoing one week of sham followed by high-definition transcranial direct current stimulation (HD-tDCS) of the motor cortex (M1) or one week of ES HD-tDCS of a brain region identified from computer modelling (Aim 2).
Protocol Amendment History 3 changes
critical Enrollment closed, study ongoing 2026-08-11
notable Primary completion pushed: 2026-07-20 -> 2026-12-20 2026-08-11
minor Completion pushed: 2026-07-20 -> 2026-12-20 2026-08-11
Trial Details
NCT Number NCT04606095
Lead Sponsor University of Michigan
Collaborators: National Center for Complementary and Integrative Health (NCCIH)
Conditions Fibromyalgia, Healthy Volunteers
Enrollment 150 participants
Start Date 2020-11-13
Primary Completion 2026-12-20 (estimated)
Study Completion 2026-12-20 (estimated)
Updated on ClinicalTrials.gov 2026-08-10