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COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE)

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

The 50 most recent of 105 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fieldsv105
  2. Phase: Phase 1/2 to Not applicablev104 Show 5 more changesShow less
    • Results first posted: May 12, 2026
    • Primary endpoint revised
    • Eligibility criteria expanded, about 11 words
    • Secondary endpoints shortened, about 13 words
    • Study description shortened, about 1 word
  3. Primary completion date changed from estimate of Dec 31, 2025 to May 5, 2025v103
  4. Re-verified, no change to tracked fieldsv102
  5. Enrollment target: 41 to 48v101
Show 45 earlier versionsHide 45 earlier versions
  1. Re-verified, no change to tracked fieldsv100
  2. Trial status: Recruiting to Active, Not Recruiting
    • Enrollment target: estimated 90 to confirmed 41
    • Site details revised
    v99
  3. 3 versions Re-verified since Jun 26, 2024, no change to tracked fieldsv96-v98
  4. Eligibility criteria shortened, about 6 wordsv95
  5. Eligibility criteria expanded, about 37 words
    • Study description shortened, about 1 word
    v94
  6. Primary completion date: Dec 31, 2023 to Dec 31, 2025
    • Study completion date: Dec 31, 2024 to Dec 31, 2026
    v93
  7. Re-verified, no change to tracked fieldsv92
  8. Eligibility criteria shortened, about 1 wordv91
  9. 5 versions Re-verified since Dec 14, 2022, no change to tracked fieldsv86-v90
  10. Eligibility criteria expanded, about 43 wordsv85
  11. Study completion date: Dec 31, 2023 to Dec 31, 2024v84
  12. 3 versions Re-verified since Jun 24, 2022, no change to tracked fieldsv81-v83
  13. Interventions: Aerobic Exercise Training with Education (Other), Education first, Exercise after (Other) to Aerobic Exercise Training (Other), Education (Other)v80
  14. Interventions: Aerobic Exercise Training (Other), Education (Other) to Aerobic Exercise Training with Education (Other), Education first, Exercise after (Other)
    • Eligibility criteria shortened, about 101 words
    v79
  15. Re-verified, no change to tracked fieldsv78
  16. Eligibility criteria expanded, about 7 words
    • Study description shortened, about 198 words
    v77
  17. 2 versions Re-verified since Feb 11, 2022, no change to tracked fieldsv75-v76
  18. Eligibility criteria shortened, about 87 words
    • Study description expanded, about 432 words
    v74
  19. 4 versions Re-verified since Aug 18, 2021, no change to tracked fieldsv70-v73
  20. Secondary endpoints: details revised at 1 of 2 entriesv69
  21. Re-verified, no change to tracked fieldsv68
  22. Study description shortened, about 416 wordsv67
  23. 2 versions Re-verified since Feb 4, 2021, no change to tracked fieldsv65-v66
  24. Eligibility criteria expanded, about 1 wordv64
  25. Start date changed from estimate of Jan 29, 2021 to Jan 22, 2021v63
  26. Start date: Jan 28, 2021 to Jan 29, 2021v62
  27. Start date: Jan 27, 2021 to Jan 28, 2021v61
  28. Start date: Jan 25, 2021 to Jan 27, 2021v60
  29. Start date: Jan 21, 2021 to Jan 25, 2021
    • Eligibility criteria expanded, about 1 word
    v59
  30. Start date: Jan 20, 2021 to Jan 21, 2021
    • Eligibility criteria expanded, about 12 words
    v58
  31. Start date: Jan 19, 2021 to Jan 20, 2021v57
  32. Start date: Jan 18, 2021 to Jan 19, 2021v56
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background: People who are recovering from COVID-19 may continue to have problems that affect their daily life. For instance, they might feel overly tired. Researchers want to learn if exercise can help people recover after COVID-19 infection. Objective: To study if participation in a rehabilitation exercise program can help people recovering from COVID-19. Eligibility: Adults ages 18-80 with a lab-confirmed SARS-CoV2 infection (the virus that causes COVID-19), and are still having some symptoms. Design: Participants will have a medical history and physical exam. They will give blood and urine samples. They will have tests to measure heart and lung function. Their blood vessels will be assessed. Participants will have a computed tomography scan of the body. They will have an ultrasound of the muscles in their arms, legs, and chest. Participants will take a 6-minute walk test (6MWT). They will take other balance and movement tests. Participants will walk on a treadmill while hooked up to a monitor. Then they will be interviewed. It will be audio-recorded. Participants will complete surveys about their symptoms and daily activities. Participants will take a smell test. For this, they will identify different smells. They will also have memory, attention, and mental functioning tests. Participants will wear an activity monitor on their wrist 24 hours a day. They will exercise 3 times a week for 10 weeks by performing cardio-type exercise for 30 minutes. They will attend education classes once a week for 10 weeks. Participants will be contacted by phone or email every 3 months for 1 year after they complete the exercise part of the study. They will wear an activity monitor for up to 2 weeks.
Trial Details
NCT Number NCT04595773
Lead Sponsor National Institutes of Health Clinical Center (CC)
Conditions
(from sponsor)		 COVID-19
Related terms Convalescence, COVID-19, Motor Activity
Enrollment 48 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov