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Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease

Study acronym: PERSEVERE
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated May 18, 2022 (before its estimated December 31, 2025 completion). Its status may not reflect the trial's current state.

Record History

See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fieldsv3
  2. Primary endpoint revised
    • Eligibility criteria shortened, about 15 words
    • Secondary endpoints revised (2)
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.
Trial Details
NCT Number NCT04578301
Lead Sponsor University Hospital, Bonn
Conditions
(from sponsor)		 Liver Cirrhosis, Portal Hypertension, Surgery, Acute-On-Chronic Liver Failure, Non-Cirrhotic Portal Hypertension
Related terms Acute-On-Chronic Liver Failure, Hypertension, Portal, Liver Cirrhosis
Enrollment 200 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov