Clinical Trial

Improving Therapeutic Learning for PTSD

Recruiting Phase 2
View on ClinicalTrials.gov →
Record status
This record was last updated August 30, 2023 (before its estimated December 2023 completion). Its status may not reflect the trial's current state.
Summary
The proposed project seeks to demonstrate the engagement of post-exposure dopamine neurotransmission and downstream acute reorganization of dopaminergic resting-state neural networks as a means of increasing consolidation of extinction memories formed during analogue exposure therapy in adult women with PTSD. Participants will include 120 women aged 21-50 with a current diagnosis of PTSD related to physical or sexual assault, English speaking, and medically healthy. Participants will complete the stages of the study across 2-3 days, depending on participant need.
Protocol Amendment History 13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2020-09-15; most recent amendment 2026-06-15.
Status change: Recruiting → Completed 2026-06-15
Status change: Not Yet Recruiting → Recruiting 2021-02-10
Trial Details
NCT Number NCT04558112
Lead Sponsor University of Wisconsin, Madison
Collaborators: National Institute of Mental Health (NIMH)
Conditions PTSD, Post Traumatic Stress Disorder
Enrollment 120 participants
Start Date 2021-02-18
Primary Completion 2023-12 (estimated)
Study Completion 2023-12 (estimated)
Updated on ClinicalTrials.gov 2023-08-30