Clinical Trial

BonE and Joint Infections - Simplifying Treatment in Children Trial

Study acronym: BEST
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
This is a multi- centre trial of children with bone and joint infections (BJIs) at eight major paediatric hospitals in Australia and New Zealand. The primary objective is to establish if in children with acute, uncomplicated BJIs, entirely oral antibiotic treatment is not inferior to initial intravenous (IV) treatment for 1 to 7 days followed by an oral antibiotic course in achieving full recovery 3 months after presentation. Children will be randomly allocated to the 'entirely oral antibiotic' group or the 'standard treatment' group.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2020-09-01; most recent amendment 2025-11-14.
Status change: Not Yet Recruiting → Recruiting 2021-09-07
Trial Details
NCT Number NCT04538053
Lead Sponsor Murdoch Childrens Research Institute
Conditions Bone Infection, Septic Arthritis, Bone and Joint Infection, Osteomyelitis
Enrollment 285 participants
Start Date 2021-06-01
Primary Completion 2026-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2025-11-17