Prediction of Inspiratory Effort Response to High PEEP in Patients Recovering From ARDS

Spontaneous breathing during the transition from controlled to assisted ventilation in ARDS may be harmful, as high respiratory drive can generate large transpulmonary pressure swings and worsen lung injury. Higher PEEP may mitigate this by reducing inspiratory effort and lung stress, but patient response is variable and difficult to predict. While improved lung compliance appears to mediate the protective effects of PEEP, its bedside assessment is complex. Preclinical data suggest that changes in compliance are inversely reflected by changes in respiratory rate, but this relationship and its clinical utility in ARDS patients remain unclear.

NCT Number	NCT04524091
Lead Sponsor	Sanatorio Anchorena San Martin
Conditions	Acute Respiratory Distress Syndrome
Enrollment	30 participants
Start Date	2020-08-01
Primary Completion	2026-04-01 (estimated)
Study Completion	2026-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-16