Multimodal Prehabilitation During Chemotherapy in Patients With Colorectal Liver Metastases

Liver resection is the only curative treatment for patients with colorectal liver metastases (CRLM). Most patients undergo chemotherapy (CT) before liver surgery. CT objectively decreases patient functional capacity. It has already been demonstrated that a structured training program carried out during the 4 weeks following CT, while the patient is waiting for liver resection, is able to return the functional capacity to baseline levels. Despite this, multimodal prehabilitation programs (MPP) during preoperative CT have not been evaluated or implemented. The aim of this study is to investigate whether a 16-week MPP applied during and following CT in CRLM patients will result in a significant increase in physical fitness when compared to those that undergo MPP only during the 4-weeks, between the end of CT and liver resection.

NCT Number	NCT04520737
Lead Sponsor	Institut Investigacio Sanitaria Pere Virgili
Conditions	Prehabilitation, Neoadjuvant Therapy, Liver Metastases
Enrollment	84 participants
Start Date	2021-02-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2024-07-01