Clinical Trial

Effects of 5HTP on the Injured Human Spinal Cord

Study acronym: 5-HTP only
Recruiting Phase 2/3
View on ClinicalTrials.gov →
Record status
This record was last updated August 27, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2020-08-17; most recent amendment 2025-08-20.
Status change: Active, Not Recruiting → Recruiting 2023-08-03
Status change: Recruiting → Active, Not Recruiting 2022-10-13
Trial Details
NCT Number NCT04520178
Lead Sponsor University of Alberta
Collaborators: Wings for Life
Conditions Spinal Cord Injuries
Enrollment 30 participants
Start Date 2020-07-01
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-12-30 (estimated)
Updated on ClinicalTrials.gov 2025-08-27