Clinical Trial

Adjuvant Chemotherapy of Three-step Regimen in BRCA1/2 Wide Type Ovarian Cancer (ACTS-2)

Recruiting Phase 3
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Summary
Ovarian cancer was mostly diagnosed at late stage (III/IV) with high rate of recurrence after first line of therapy by optimal cytoreductive sugery and 6cycle of TP chemotherapy. There is no standard maintainance therapy for BRCA1/2 wide-type ovarian cancer. We developed an adjuvant chemotherapy of "three steps" (ACTS). It is adding CTX+VP-16(second step) 6cycle and CTX+CBP(third steps) to firstline chemotherapy (first step). The aim of this study is to verify the effectivity and safety of ACTS in BRCA1/2 wide-type ovarian cancer patients.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2020-08-19; most recent amendment 2022-07-25.
Status change: Not Yet Recruiting → Recruiting 2022-07-25
Trial Details
NCT Number NCT04520074
Lead Sponsor Fudan University
Conditions Ovarian Cancer
Enrollment 590 participants
Start Date 2021-10-08
Primary Completion 2027-09 (estimated)
Study Completion 2030-09 (estimated)
Updated on ClinicalTrials.gov 2022-07-27