Effects of Post-Operative Sedation for Endovascular Thrombectomy

Studies from our lab indicated that long-term sedation is protective in mice with midbrain infarct. To assess whether post-operative sedation has protective effects on clinical outcomes in patients with ischemic stroke undergoing endovascular thrombectomy (ET), a multi-center, randomized clinical trial will be carried out (POSET study). In POSET study, patients receiving ET for acute ischemic stroke under general anesthesia will be randomly assigned to the control group (Con group) and the post-operative sedation group (POS group). Patients in the Con group will be recovered and extubated immediately after the surgery, whereas those in the POS group will be sedated with propofol and dexmedetomidine for another 6hrs before extubation. The primary endpoint is the score on the modified Rankin Scale assessed at 90±7 days after randomization. The hypothesis is that patients in the POS group will have improved clinical outcome in 3 months after surgery.

NCT Number	NCT04517383
Lead Sponsor	RenJi Hospital Collaborators: Changhai Hospital, Huashan Hospital, Shanghai Tongji Hospital, Tongji University School of Medicine, Beijing Chao Yang Hospital, Shanghai 6th People's Hospital, Tongji University, Henan Provincial People's Hospital, Second Affiliated Hospital, Zhejiang University, School of Medicine, Fujian Provincial Hospital, The First People's Hospital of Lianyungang, The Affiliated Hospital of Ningbo University
Conditions	Acute Ischemic Stroke, Endovascular Thrombectomy
Enrollment	1,286 participants
Start Date	2021-11-24
Primary Completion	2025-12-30 (estimated)
Study Completion	2025-12-30 (estimated)
Updated on ClinicalTrials.gov	2024-07-03