Clinical Trial

4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)

Active, Not Recruiting Phase 1/2
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Record status
This record was last updated March 21, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a Phase 1/2 multicenter study with two parallel parts: an observational natural history cohort and an open-label, prospective interventional trial in males with non-syndromic X-linked retinitis pigmentosa (XLRP) due to mutations in the gene encoding retinitis pigmentosa GTPase regulator (RPGR).
Protocol Amendment History 14 amendments
This ClinicalTrials.gov record has been amended 14 times since 2020-08-14; most recent amendment 2025-03-19.
Status change: Recruiting → Active, Not Recruiting 2023-01-30
Trial Details
NCT Number NCT04517149
Lead Sponsor 4D Molecular Therapeutics
Conditions X-Linked Retinitis Pigmentosa
Enrollment 21 participants
Start Date 2020-06-09
Primary Completion 2026-06 (estimated)
Study Completion 2029-05 (estimated)
Updated on ClinicalTrials.gov 2025-03-21