Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT04502407 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer

StatusActive, Not Recruiting
PhasePhase 2
Started2021-02-16
View on ClinicalTrials.gov ↗

Amendment history

2026-08-03
4 amendments v14-v17
4 re-verifications since 2025-09-02, no change to tracked fields
2025-02-11
Recruiting→Active, Not Recruiting Study Status, Contacts/Locations v13
Trial statusRecruiting→Active, Not Recruiting
Study sitesdetails revised at 4 of 4 sites
2025-02-03
2 amendments v11-v12
2 re-verifications since 2024-08-01, no change to tracked fields
2024-02-02
Active, Not Recruiting→Recruiting Study Status, Contacts/Locations v10
Trial statusActive, Not Recruiting→Recruiting
Study sitesdetails revised at 4 of 4 sites
2024-02-01
Study Status v9
Primary completion date2023-12-15→2026-12-15
Completion date2025-09-15→2029-12-15
Show 8 earlier versions
2023-10-24
Recruiting→Active, Not Recruiting Study Status, Contacts/Locations v8
Trial statusRecruiting→Active, Not Recruiting
Study sitesdetails revised at 4 of 4 sites
2023-10-09
Study Status v7
Primary completion date2023-09-15→2023-12-15
2023-03-02
Study Status, Study Description, Study Design v6
Enrollment target36→40
2022-07-06
Study Status v5
Re-verified, no change to tracked fields
2022-01-07
Study Status, Contacts/Locations v4
Study sites3→4
2021-10-04
Study Status v3
Re-verified, no change to tracked fields
2021-04-14
Study Status, Contacts/Locations v2
Study sitesdetails revised at 2 of 3 sites
2021-02-16
Not Yet Recruiting→Recruiting Study Status, Sponsor/Collaborators, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2020-10-01→confirmed 2021-02-16
Study sites2→3
2020-08-04
Original filing
This study will enroll patients with HPV-associated oropharyngeal cancer, undergoing resection of all gross visible disease at the primary site and in the lymph nodes. A total of 40 patients who have had or will require surgery to remove cancer cells prior to starting chemoradiation may be enrolled. All eligible patients will receive de-intensified cisplatin-based chemoradiation, with high-risk patients receiving a higher dose and longer treatment period than other patients on the study. The study will assess whether a de-intensified version of standard chemoradiation treatment will be just as effective in treating HPV-associated oropharyngeal cancer while causing less side effects than standard dosing.
Trial Details
NCT Number NCT04502407
Lead Sponsor Cedars-Sinai Medical Center
Conditions HPV Positive Oropharyngeal Squamous Cell Carcinoma
Enrollment 40 participants
Start Date 2021-02-16
Primary Completion 2026-12-15 (estimated)
Study Completion 2029-12-15 (estimated)
Updated on ClinicalTrials.gov 2026-08-05