TO-ChERIsH: Trajectory of Cardiovascular Ageing, Its Determinants and Impact on Health

Specific Aim 1: To determine longitudinal changes in CV ageing (changes in CV imaging) over time. Hypothesis: There are differences in rates of CV ageing over time. Specific Aim 2: To study determinants of CV ageing To assess how biological pathways affect CV ageing by studying the relationships between biological signatures measured in longitudinal biospecimens are associated with CV ageing. Hypothesis: Antecedent biological markers are associated with progression of CV ageing. Specific Aim 3: To determine the impact of CV ageing progression on the development of clinical CVD and the overall physical, cognitive and functional health of the elderly. Hypothesis: Those with stable CV imaging phenotypes have lower incidence of clinical CVD and also better overall health in ageing, compared to those with rapid deterioration (unhealthy CV ageing).

NCT Number	NCT04501562
Lead Sponsor	National Heart Centre Singapore
Conditions	Cardiac Ageing
Enrollment	500 participants
Start Date	2019-05-13
Primary Completion	2049-12 (estimated)
Study Completion	2049-12 (estimated)
Updated on ClinicalTrials.gov	2025-06-05