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Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Study acronym: INCORE
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 17, 2026 (before its estimated March 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: Oct 2025 to Mar 2026
    • Study completion date: Dec 2025 to Mar 2026
    v6
  2. Primary completion date: Nov 2023 to Oct 2025
    • Study completion date: Nov 2023 to Dec 2025
    v5
  3. Re-verified, no change to tracked fieldsv4
  4. Primary and study completion dates: Nov 2022 to Nov 2023v3
  5. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Aug 2020 to Aug 14, 2020
    • Site details revised
    v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and mortality and higher economic costs. Preoperative risk factors of postoperative neurocognitive dysfunctions, such as decreased neuropsychometric performance or decreased cognitive daily activities, can be interpreted as reduced cognitive reserve. The aim of this study is to build up cognitive reserves to protect against the development of POD and POCD through preoperative, home-based, cognitive training.
Trial Details
NCT Number NCT04493996
Lead Sponsor Heart and Brain Research Group, Germany
Conditions
(from sponsor)		 Postoperative Cognitive Decline, Postoperative Delirium, Postoperative Cognitive Dysfunction
Related terms Emergence Delirium, Postoperative Cognitive Complications
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov