Clinical Trial

Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Study acronym: INCORE
Recruiting
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Record status
This record was last updated February 17, 2026 (before its estimated March 2026 completion). Its status may not reflect the trial's current state.
Summary
Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and mortality and higher economic costs. Preoperative risk factors of postoperative neurocognitive dysfunctions, such as decreased neuropsychometric performance or decreased cognitive daily activities, can be interpreted as reduced cognitive reserve. The aim of this study is to build up cognitive reserves to protect against the development of POD and POCD through preoperative, home-based, cognitive training.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2020-07-30; most recent amendment 2026-02-13.
Status change: Not Yet Recruiting → Recruiting 2020-08-18
Trial Details
NCT Number NCT04493996
Lead Sponsor Heart and Brain Research Group, Germany
Conditions Postoperative Cognitive Decline, Postoperative Delirium, Postoperative Cognitive Dysfunction
Enrollment 100 participants
Start Date 2020-08-14
Primary Completion 2026-03 (estimated)
Study Completion 2026-03 (estimated)
Updated on ClinicalTrials.gov 2026-02-17