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Dose Escalation Study of Intravitreal 4D-110 in Patients With Choroideremia

StatusActive, Not Recruiting
PhasePhase 1
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Jun 2024 to May 26, 2027 Completion date: Jun 2027 to Aug 31, 2027v8 Show 1 more changeShow less
    • Completion date: Jun 2027 to Aug 31, 2027
  2. Study description revised Study arms: 2 to 3v7 Show 1 more changeShow less
    • Study arms: 2 to 3

    See this version in full on ClinicalTrials.gov ↗

  3. Primary completion date: Nov 2021 to Jun 2024 Trial status: Recruiting to Active, Not Recruiting · Enrollment target: estimated 15 to confirmed 13 · Completion date: May 2023 to Jun 2027 · 1 morev6 Show 4 more changesShow less
    • Trial status: Recruiting to Active, Not Recruiting
    • Enrollment target: estimated 15 to confirmed 13
    • Completion date: May 2023 to Jun 2027
    • Site details revised at 2 of 2 sites
  4. Collaborators shortened, about 3 wordsv5 See this version in full on ClinicalTrials.gov ↗
  5. 3 versions Re-verified since Jul 28, 2020, no change to tracked fieldsv2-v4
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study will evaluate safety, tolerability, and preliminary efficacy of a single intravitreal (IVT) injection of a recombinant adeno-associated virus (AAV) gene therapy, 4D-110, in male patients with genetically-confirmed Choroideremia (CHM).
Trial Details
NCT Number NCT04483440
Lead Sponsor 4D Molecular Therapeutics
Conditions Choroideremia
Enrollment 13 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov