Clinical Trial

Replacing Protein Via Enteral Nutrition in Critically Ill Patients

Study acronym: REPLENISH
Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated September 8, 2025 (before its estimated November 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
The investigator will investigate the effect of supplemental enteral protein (1.2 g/kg/day) added to standard formula to achieve high amount of enteral protein (range 2-2.4 g/kg/day) given from ICU day 5 until ICU discharge up to ICU day 90 as compared to no supplemental enteral protein to achieve moderate amount enteral protein (0.8-1.2 g/kg/day), given in conjunction with similar amounts of stepwise caloric administration in the two groups on all-cause 90-day mortality.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2020-07-14; most recent amendment 2025-08-31.
Status change: Not Yet Recruiting → Recruiting 2021-02-23
Trial Details
NCT Number NCT04475666
Lead Sponsor King Abdullah International Medical Research Center
Conditions Critical Illness, Nutrition Disorders
Enrollment 2,502 participants
Start Date 2020-09-21
Primary Completion 2025-11-30 (estimated)
Study Completion 2026-04-30 (estimated)
Updated on ClinicalTrials.gov 2025-09-08