Optimizing Volunteer Comfort for Transcranial Electrical Stimulation (TES): An Assessment

Transcranial electrical stimulation (TES) utilizing weak electrical fields (\<5 milliamps of current - as proposed in the present pilot study) is an extremely safe therapeutic technique in use for over 40 years. During that time, TES has never been associated with a serious adverse event in a research setting nor a serious reported adverse event in a clinical setting. The main side effect associated with TES is irritation of the skin beneath the electrodes (as is commonly found from similar preparations used for polysomnography). The purpose of this pilot study is to identify the type of electrode preparation that maximizes subject comfort during transdermal/transcranial electrical stimulation (TES) using the NeuroConn DC Plus Stimulator.

NCT Number	NCT04474015
Lead Sponsor	U.S. Army Medical Research and Development Command Collaborators: Walter Reed Army Institute of Research (WRAIR)
Conditions	Performance Enhancing Product Use, Sleep
Enrollment	75 participants
Start Date	2014-05-24
Primary Completion	2029-02-12 (estimated)
Study Completion	2029-02-12 (estimated)
Updated on ClinicalTrials.gov	2025-03-28