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Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia

Study acronym: PREVENT
StatusActive, Not Recruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Lead sponsor: Ohio State University Comprehensive Cancer Center to Ohio State University
    • Primary and study completion dates: Dec 31, 2025 to Dec 31, 2026
    v6
  2. Primary completion date: Dec 31, 2024 to Dec 31, 2025v5
  3. Primary completion date: Dec 31, 2021 to Dec 31, 2024v4 Show 4 more changesShow less
    • Trial status: Recruiting to Active, Not Recruiting
    • Enrollment target: estimated 100 to confirmed 37
    • Study sites: 8 to 7
    • Study completion date: Dec 31, 2022 to Dec 31, 2025
  4. Study sites: 7 to 8v3
  5. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 7
    • Start date changed from estimate of Jul 1, 2020 to Aug 28, 2020
    v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Low doses of radiation in the form of chest x-rays has been in the past to treat people with pneumonia. This treatment was thought to reduce inflammation and was found to be effective without side effects. However, it was an expensive treatment and was eventually replaced with less expensive treatment options like penicillin. The COVID-19 virus has emerged recently, causing high rates of pneumonia in people. The authors believe that giving a small dose of radiation to the lungs may reduce inflammation and neutralize the pneumonia caused by COVID-19. For this study, the x-ray given is called radiation therapy. Radiation therapy uses high-energy X-ray beams from a large machine to target the lungs and reduce inflammation. Usually, it is given at much higher doses to treat cancers. The purpose of this study is to find out if adding a single treatment of low-dose x-rays to the lungs might reduce the amount of inflammation in the lungs from COVID-19 infection, which could reduce the need for a ventilator or breathing tube.
Trial Details
NCT Number NCT04466683
Lead Sponsor Ohio State University
Collaborators: Varian Medical Systems
Conditions
(from sponsor)		 Covid-19, Sars-CoV2, Pneumonia
Related terms COVID-19, Pneumonia
Enrollment 37 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov