Clinical Trial

Opioid Analgesic Reduction Study

Study acronym: OARS
Active, Not Recruiting Phase 3
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Summary
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified randomized clinical trial will be conducted to test the hypothesis that a combination of over-the-counter non-opioid containing analgesics is at least as, if not more, effective (non-inferior) than the most commonly prescribed opioid analgesic. The impacted 3rd molar extraction model will be used due to the predictable severity of the post-operative pain and generalizability of results. This double-blind, prospective, stratified, randomized pragmatic clinical trial will use the impacted 3rd molar extraction pain model.
Protocol Amendment History 13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2020-06-29; most recent amendment 2026-03-17.
Status change: Recruiting → Active, Not Recruiting 2023-09-22
Status change: Not Yet Recruiting → Recruiting 2021-02-18
Trial Details
NCT Number NCT04452344
Lead Sponsor Rutgers, The State University of New Jersey
Collaborators: National Institute of Dental and Craniofacial Research (NIDCR), University of Rochester, University of Maryland, Baltimore, University of Illinois at Chicago, University of Michigan
Conditions Opioid Use
Enrollment 1,815 participants
Start Date 2021-01-04
Primary Completion 2023-07-07 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-03-31