Clinical Trial

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

Study acronym: DEFINE GPS
Enrolling by Invitation
View on ClinicalTrials.gov →
Record status
This record was last updated January 20, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR Co-Registration using commercially available Philips pressure guidewires and the SyncVision co-registration system, employing an adaptive design study for interim sample size re-estimation.
Protocol Amendment History 22 amendments
This ClinicalTrials.gov record has been amended 22 times since 2020-06-25; most recent amendment 2025-01-16.
Status change: Not Yet Recruiting → Enrolling by Invitation 2021-06-25
Trial Details
NCT Number NCT04451044
Lead Sponsor Philips Clinical & Medical Affairs Global
Conditions Coronary Artery Disease, Ischemic Heart Disease
Enrollment 3,212 participants
Start Date 2021-06-17
Primary Completion 2026-06 (estimated)
Study Completion 2028-06 (estimated)
Updated on ClinicalTrials.gov 2025-01-20