Clinical Trial

Multivessel TALENT

Active, Not Recruiting
View on ClinicalTrials.gov →
Summary
Multivessel TALENT is a prospective, randomized, multi-center study comparing clinical outcomes between SUPRAFLEX Cruz and SYNERGY in approximately 1550 patients with de-novo three vessel disease undergoing percutaneous coronary intervention (PCI). Patients will be treated according to "state of art PCI"; not only treatment strategies based on the latest ESC guideline, such as SYNTAX Score II recommendation, Heart Team discussion, post-procedure intravascular imaging optimization, cholesterol reduction by statin or PCSK-9 inhibitor, but also exploratory treatment strategies based on the latest evidence, such as physiological assessment using quantitative flow ratio and prasugrel monotherapy following 1-month dual antiplatelet therapy after PCI.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2020-05-12; most recent amendment 2026-02-26.
Status change: Recruiting → Active, Not Recruiting 2024-09-30
Status change: Not Yet Recruiting → Recruiting 2021-03-02
Trial Details
NCT Number NCT04390672
Lead Sponsor National University of Ireland, Galway, Ireland
Conditions Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases, Cardiovascular Diseases, Arterial Occlusive Diseases, Vascular Diseases
Enrollment 1,550 participants
Start Date 2020-09-22
Primary Completion 2025-09-23 (estimated)
Study Completion 2026-09 (estimated)
Updated on ClinicalTrials.gov 2026-02-27