AXillary Surgery After NeoAdjuvant Treatment

The optimal surgical axillary staging technique in patients who convert from the clinically positive to clinically negative lymph node status under neoadjuvant therapy (cN+ → ycN0) remains to be clarified. Different strategies (axillary lymph node dissection, sentinel node biopsy, targeted axillary dissection) are currently used in different countries. A prospective analysis comparing these techniques regarding feasibility, safety, morbidity and surgical effort is urgently needed. Due to high complexity and discordant recommendations, a randomized trial comparing different techniques is hardly feasible. Therefore, the EUBREAST study group decided to initiate a prospective cohort study as an international project that aims at comparatively evaluating data on axillary staging after neoadjuvant therapy.

NCT Number	NCT04373655
Lead Sponsor	European Breast Cancer Research Association of Surgical Trialists Collaborators: AWOgyn, AGO-B, North Eastern German Society of Gynaecological Oncology, GBG Forschungs GmbH, Claudia von Schilling Foundation for Breast Cancer Research, Ehmann-Stiftung Savognin
Conditions	Breast Cancer
Enrollment	3,000 participants
Start Date	2020-04-28
Primary Completion	2030-04 (estimated)
Study Completion	2030-04 (estimated)
Updated on ClinicalTrials.gov	2025-03-03